Iron-catalyzed radical aryldifluoromethylation of activated alkenes to difluoromethylated oxindoles.
نویسندگان
چکیده
An iron-catalyzed aryldifluoromethylation of activated alkenes under mild reaction conditions has been developed, which is a rare example where a cosolvent is used to improve the reaction yield along with Fenton's reagent and thus provides an economic and green method for the synthesis of a variety of difluoromethylated oxindoles. Preliminary mechanistic investigations indicate a radical addition path.
منابع مشابه
Pd(0)-Catalyzed radical aryldifluoromethylation of activated alkenes.
A Pd(0)-catalyzed intramolecular aryldifluoromethylation of activated alkenes under mild reaction conditions has been developed. This reaction provides a new method for construction of a variety of difluoromethylated oxindoles. Mechanistic investigations indicate that a difluoromethyl radical, which was triggered by Pd(0), initiated the cascade sequence through an addition to the alkene.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 30 شماره
صفحات -
تاریخ انتشار 2014